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    hub sciencedirect scopus applications register login login go to scival suite username: password: remember me | not registered? Forgotten your username or password? Go to athens / institution login remote access activation home publications search my settings my alerts shopping cart help export citation purchase more options... Email article signed up for journal alerts [remove] alert me about new articles in this journal your selection(s) could not be saved due to an internal error. buy viagra online buy generic viagra viagra without a doctor prescription viagra online generic viagra online canada viagra for sale viagra without a doctor prescription cheap viagra from canada Please try again. Search     all fields     author advanced search     journal/book title     volume   issue   page search tips article outline is loading... Javascript required for article outline the journal of pediatrics volume 114, issue 4, part 1, april 1989, pages 555–560 original article incidence, severity, and prevention of infections in chronic granulomatous disease md r. Mouy a , b , md a. Fischer a , b , , md e. Vilmer a , b , md r. Seger a , b , md c. Griscelli a , b a unité d'immunologie et d'hématologie, department of pediatrics, hôpital des enfants-malades, paris, france b kinderspital, zürich, switzerland received 29 february 1988 accepted 21 october 1988 available online 13 march 2006 how to cite or link using doi permissions & reprints view full text purchase $31. 50 we retrospectively analyzed the frequency and nature of infections occurring in 48 patients with chronic granulomatous disease. The long-term use of trimethoprim-sulfamethoxazole and ketoconazole as a preventive therapy for infections has also been evaluated. Lymphadenitis, lung infections, dermatitis, enteral infections, and hepatic abscesses were the most frequent infections. Staphylococcus aureus, salmonella, and aspergillus were the main microor-ganisms encountered. Twelve patients died: five from lung aspergillosis, three from hepatic abscesses, two from pneumonopathy of unknown origin, one from salmonellosis, and one from another probable infection that could not be proved. The actuarial survival rate was 50% at 10 years of age, with a prolonged plateau thereafter. There was no difference in survival rates between patients with x-linked and those with autosomal recessive chronic granulomatous disease. The 8-year actuarial survival rate was significantly higher for patients born in 1978 or afterward than for patients born before 1978 (92. 9% vs 70. 5%). A retrospective analysis of the occurrence of bacterial and fungal infections in patients who received trimethoprim-sulfamethoxazole and ketoconazole as infection prophylaxis indicated that.

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